Bradykinin Receptor Antagonist

Bradykinin Receptor Antagonists (27):

Cat. No.	Product Name	Effect	Purity

HY-17446

Icatibant	Antagonist	99.63%
Icatibant (HOE-140) is a potent and specific peptide antagonist of bradykinin B2 receptor with IC₅₀ and K_i of 1.07 nM and 0.798 nM respectively.

HY-108896

Icatibant acetate	Antagonist	99.65%
Icatibant acetate (HOE-140 acetate) is a potent and specific peptide antagonist of bradykinin B2 receptor with an IC₅₀ and K_i of 1.07 nM and 0.798 nM respectively.

HY-15039

SSR240612	Antagonist	99.51%
SSR240612 is a potent, and orally active specific non-peptide bradykinin B1 receptor antagonist, with K_is of 0.48 nM and 0.73 nM for B1 kinin receptors of human fibroblast MRC5 and HEK cells expressing human B1 receptors, 481 nM and 358 nM for B2 receptors of guinea pig ileum membranes and CHO cells expressing human B1 receptor, respectively.

HY-121156A

Anatibant hydrochloride	Antagonist
Anatibant (LF 16-0687; XY-2405) hydrochloride is a selective non-peptide bradykinin B2 receptor antagonist. Anatibant hydrochloride binds to the human, rat and guinea-pig recombinant B2 receptor with K_i values of 0.67 nM, 1.74 nM and 1.37 nM, respectively. Anatibant hydrochloride crosses the blood-brain barrier (BBB). Anatibant hydrochloride can be used in research on brain damage diseases.

HY-147273

Fulimetibant	Antagonist	99.74%
Fulimetibant is a bradykinin receptor antagonist.

HY-103290

R715	Antagonist	99.45%
R715 is a selective bradykinin B1 receptor antagonist. R715 significantly attenuates the hyperalgesic effect developed in Streptozotocin(HY-13753)-diabetic mice.

HY-103289

MEN 11270	Antagonist	99.15%
MEN 11270, a cyclic decapeptide, is a B2 kinin receptor antagonist. MEN 11270 bound with high-affinity to the B2 kinin receptor constitutively expressed by WI38 human fibroblasts, inhibiting 3H-bradykinin (BK) with a pK_i value of 10.3.

HY-15043

ELN-441958	Antagonist	99.51%
ELN-441958 is a potent, neutral, competitive and selective bradykinin B₁ receptor antagonist with a K_i of 0.26 nM against native human bradykinin B₁ receptor. ELN-441958 has high oral bioavailability, and has low CNS exposure in the mouse.

HY-P4676

Lys-(Des-Arg9,Leu8)-Bradykinin	Antagonist	98.23%
Lys-(Des-Arg9,Leu8)-Bradykinin is a bradykinin B1 receptor antagonist.

HY-121156

Anatibant	Antagonist
Anatibant (LF 16-0687; XY-2405) is a selective non-peptide bradykinin B2 receptor antagonist. Anatibant binds to the human, rat and guinea-pig recombinant B2 receptor with K_i values of 0.67 nM, 1.74 nM and 1.37 nM, respectively. Anatibant crosses the blood-brain barrier (BBB). Anatibant can be used in research on brain damage diseases.

HY-106277

Fasitibant free base	Antagonist
Fasitibant (free base) is a potent, selective, high affinity, and long-lasting nonpeptide bradykinin B₂ (BK₂) receptor antagonist. Fasitibant (free base) has proinflammatory effects and can be used for the research of osteoarthritis and rheumatoid arthritis.

HY-P3232

B 9430	Antagonist
B 9430 is a potent bradykinin B1/B2 receptor antagonist.

HY-106277A

Fasitibant chloride hydrochloride	Antagonist
Fasitibant chloride hydrochloride (MEN16132) is a potent, selective, high affinity, and long-lasting nonpeptide bradykinin B₂ (BK₂) receptor antagonist. Fasitibant chloride hydrochloride has proinflammatory effects and can be used for the research of osteoarthritis and rheumatoid arthritis.

HY-100301

FR167344 free base	Antagonist
FR167344 free base is an orally active, nonpeptide bradykinin receptor B2 antagonist. FR167344 free base shows a high affinity binding to the B2 receptor with an IC₅₀ value of 65 nM and no binding affinity for the B1 receptor.

HY-P1694

B4148	Antagonist
B4148 is a selective competitive bradykinin (BK) antagonist that significantly inhibits BK-induced hypotension in rats. In a rat model of endotoxin shock induced by Escherichia coli lipopolysaccharide, B4148 significantly attenuated the decrease in mean arterial blood pressure compared with the control group.

HY-P2109

JMV-1645	Antagonist
JMV-1645 is a potent and selective B₁ bradykinin receptor antagonist with a K_i value of 0.023 nM on the human cloned B₁ receptor. JMV-1645 can be utilized in trauma and infection research.

HY-158262

Bradykinin B1 receptor antagonist 1	Antagonist
Bradykinin B1 receptor antagonist 1 (compound 6B) is a potent and cross the blood-brain barrier bradykinin B1 antagonist. Bradykinin B1 receptor antagonist 1 has the potential for the research of pain.

HY-100827

Safotibant	Antagonist
Safotibant (LF22-0542) is a selective antagonist for kinin B1 receptor (BKB1R), with K_i of 0.35 and 6.5 nM, for human and mouse BKB1R, respectively. Safotibant exhibits analgesic and anti-inflammatory property in mice model.

HY-14886

Fasitibant chloride	Antagonist
Fasitibant chloride (MEN16132 free base) is a potent and selective nonpeptide bradykinin B2 receptor (B2R) antagonist. Fasitibant chloride reduces joint pain and diminishes joint oedema in Carrageenan-induced arthritis rat model.

HY-P1721

NPC 17731	Antagonist
NPC 17731 is a new bradykinin (BK) receptor antagonist. NPC 17731 antagonized both the contractile and relaxant responses caused by BK in longitudinal smooth muscle with IC₅₀ of 23 and 29 nM, respectively.

Name
Email *

	Sorry, but the email address you supplied was invalid.